Key result
A retrospective survey of 19,304 rats found an overall 0.3% incidence of endocardial proliferative lesions, with similar morphologic features in spontaneous and treatment-associated cases.
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Low incidence with morphologic overlap in rats cautions against attributing lesions to treatment; leaves open better differentiation in future preclinical studies.
Observational (n=19,304)
Sandusky et al. (1991) conducted an observational in Endocardial proliferative lesions (n=19,304). Carcinogen exposure (carbamate derivatives, N-nitroso-N-methylurea) vs. Spontaneous (untreated) was evaluated on Incidence of endocardial proliferative lesions. A retrospective survey of 19,304 rats found an overall 0.3% incidence of endocardial proliferative lesions, with similar morphologic features in spontaneous and treatment-associated cases.
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