Key result
Genetic factors significantly contributed to ambulatory heart rate variability, accounting for 35% to 47% of the variance in the SDNN index and 40% to 48% of the variance in RMSSD.
Observational (n=772)
Ambulatory heart rate variability measures are highly heritable traits, supporting their potential use in genetic association studies for cardiovascular disease risk.
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Ambulatory HRV heritability supports genetic association studies for CVD risk; clinical utility requires prospective validation.
Kupper et al. (2004) conducted an observational in Healthy (n=772). Genetic factors was evaluated on Genetic contribution to the mean ambulatory SDNN index and RMSSD. Genetic factors significantly contributed to ambulatory heart rate variability, accounting for 35% to 47% of the variance in the SDNN index and 40% to 48% of the variance in RMSSD.
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