Key result
Surgical correction of aortic coarctation in children reduced mean plasma renin activity from 21.4 ng/ml/hour preoperatively to 5.5 ng/ml/hour at 32 to 51 months postoperatively.
Why the study?
Does surgical correction of aortic coarctation reduce plasma renin activity in children?
Observational (n=8)
Does surgical correction of aortic coarctation reduce plasma renin activity in children?
Surgical correction of aortic coarctation significantly reduces plasma renin activity, providing evidence for the role of increased renin-angiotensin activity in this condition.
Answers are grounded in this paper and cite their sources.
Suggests renin-angiotensin activation in pediatric coarctation; leaves open confirmation in prospective studies.
We studied plasma renin activity (PRA) in eight children before and after surgical correction of aortic coarctation. These eight children underwent a combination of low-sodium diet and diuresis before surgery, and PRA was measured shortly thereafter. Thirty-two to 51 months after successful surgical correction, PRA was measured again. The mean PRA was 21.4 +/- 1.3 ng/ml/hour (+/- SD) preoperatively and 5.5 +/- 1.5 ng/ml/hour postoperatively. These findings provide further evidence of the significance of increased renin-angiotensin activity in patients with aortic coarctation.
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Parker et al. (1982) conducted an observational in aortic coarctation (n=8). Surgical correction vs. Preoperative state was evaluated on Plasma renin activity (PRA). Surgical correction of aortic coarctation in children reduced mean plasma renin activity from 21.4 ng/ml/hour preoperatively to 5.5 ng/ml/hour at 32 to 51 months postoperatively.
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