Key result
Surgery for aortic coarctation normalized pre-operatively low plasma renin activity levels, suggesting the renin-angiotensin system does not directly maintain hypertension in these patients.
Why the study?
Does surgical repair of aortic coarctation affect plasma renin activity in patients with this condition?
Observational (n=11)
Does surgical repair of aortic coarctation affect plasma renin activity in patients with this condition?
The renin-angiotensin system does not appear to be directly involved in maintaining hypertension in patients with aortic coarctation, as renin activity is low pre-operatively and normalizes after surgery.
Answers are grounded in this paper and cite their sources.
Questions role of renin-angiotensin blockade in aortic coarctation hypertension; leaves open other mechanisms and requires prospective trials.
Plasma renin acitivity was measured in II cases of coarctation of the aorta before and after operation. The values of plasma renin activity in the recumbent position before operation were significantly lower than in the control group. After surgery plasma renin activity rose to normal levels. There was no correlation between plasma renin activity levels and arterial blood pressure. The renin-angiotensin system seems not to be involved directly in the maintenance of hypertension in patients with aortic coarctation.
No takes yet. Share an insight, caveat, or question.
Markiewicz et al. (1975) conducted an observational in Coarctation of the aorta (n=11). Surgery vs. Pre-operative state and control group was evaluated on Plasma renin activity. Surgery for aortic coarctation normalized pre-operatively low plasma renin activity levels, suggesting the renin-angiotensin system does not directly maintain hypertension in these patients.
Synapse has enriched 10 related papers. Consider them for comparative context: