Key result
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are the main natural target for specific heart rate-lowering agents such as ivabradine, with new pharmacological tools emerging.
Design
Review
Authors
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Supports HCN targeting for rate control; leaves open clinical validation of emerging modulators.
This review summarizes the molecular biology of HCN pacemaker channels and highlights emerging pharmacological agents that directly inhibit the I(f) current to lower heart rate.
Bois et al. (2007) reported a review. Pacemaker channel inhibitors (e.g., ivabradine, alinidine) was evaluated. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are the main natural target for specific heart rate-lowering agents such as ivabradine, with new pharmacological tools emerging.
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