Key result
Review outlines cardiac f-channel mechanisms and therapeutic implications of I(f) inhibitors like ivabradine in CVD.
Why the study?
Currently available heart rate-lowering drugs have multiple cardiovascular effects, some undesired, motivating interest in agents exclusively targeting sinus node pacemaker activity.
Design
Review of cardiac f-channels and I(f)-current inhibitors
Authors
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May support selective heart-rate lowering without off-target effects; leaves open whether dedicated trials will confirm outcome benefit.
This review outlines the basic properties of cardiac f-channels and the therapeutic potential of I(f)-current inhibitors like ivabradine for heart rate lowering in cardiovascular disease.
Dilaveris et al. (2006) conducted a review in Cardiovascular Disease. I(f)-current inhibitors (ivabradine) was evaluated. This review outlines the basic properties of cardiac f-channels and the mode of action and therapeutic implications of I(f)-current inhibitors such as ivabradine in cardiovascular disease.
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