Why the study?
Does ORG 6001 reduce ST-segment elevation produced by coronary occlusion in dogs?
Does ORG 6001 reduce ST-segment elevation produced by coronary occlusion in dogs?
The anti-dysrhythmic aminosteroid ORG 6001 reduces ST-segment elevation during acute coronary occlusion in a canine model, potentially by reducing ischemia or preventing potassium egress.
ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.
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Marshall et al. (1977) studied this question.
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