Key result
Pregnancy in dogs increased myocardial eNOS and SOD-1 expression, enhancing nitric oxide-dependent reduction in myocardial oxygen consumption (34% vs 24% decrease with bradykinin).
Why the study?
Does pregnancy alter the nitric oxide-dependent coupling of myocardial oxygen consumption and coronary vascular dynamics in dogs?
Population
Awake dogs studied before and at 40 days, 50 days, and 60 days of pregnancy and at approximately 14 days…
Comparison
Pregnancy and in vitro administration of… vs Controls (before pregnancy)
Design
Preclinical
Follow-up
up to approximately 14 days postpartum
Authors
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Hypothesis-generating for pregnancy-induced myocardial adaptations in canines; leaves open translation to human cardiac physiology.
Does pregnancy alter the nitric oxide-dependent coupling of myocardial oxygen consumption and coronary vascular dynamics in dogs?
Absolute Event Rate: 34% vs 24%
Pregnancy in dogs increases myocardial eNOS and SOD-1 expression, enhancing nitric oxide-dependent control of myocardial oxygen consumption and coronary vasodilation.
Williams et al. (2007) studied Pregnancy. Pregnancy vs. Pre-pregnancy (controls) was evaluated on Decrease in myocardial oxygen consumption (MVO2) in response to bradykinin. Pregnancy in dogs increased myocardial eNOS and SOD-1 expression, enhancing nitric oxide-dependent reduction in myocardial oxygen consumption (34% vs 24% decrease with bradykinin).
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