Key result
A computational model of the ryanodine receptor reproduced current/voltage curves and suggested the selectivity filter contains a DDDD locus, acting as a multi-ion channel.
Population
Computational model of a single, open ryanodine receptor ion channel, including cardiac RyR2 and skeletal…
Comparison
Electrodiffusion model of finite-sized ions vs Previously applied barrier models
Design
Preclinical
Authors
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Computational RyR model supports multi-ion selectivity at DDDD locus; leaves open in vivo cardiac relevance pending mammalian validation.
A novel electrodiffusion model of the ryanodine receptor reveals it functions as a multi-ion channel whose selectivity is driven by charge/space competition at the D4899 residue.
Gillespie et al. (2005) studied this question. Computational modeling of ion permeation and selectivity was evaluated on Current/voltage curves and ion selectivity of RyR. A computational model of the ryanodine receptor reproduced current/voltage curves and suggested the selectivity filter contains a DDDD locus, acting as a multi-ion channel.
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