Key result
Recent advances in ryanodine receptor structure and dynamic organization provide new insights into channel gating mechanisms and potential targets for RyR-focused therapies.
Understanding the structural and dynamic organization of ryanodine receptors provides insights into channel gating and potential targets for new therapies.
Ryanodine receptor Ca2+ release channels (RyR) are the largest intracellular ion channels known. The primary physiological role of the RyR is to provide a ligand-regulated pathway for the release of stored Ca2+ to regulate a diverse array of cellular processes. This article highlights advances in RyR channel structure, shedding new light on closed-to-open channel transitions and on the mechanisms of channel gating in health and disease. We also evaluate how recent studies on the self-association of RyR in situ have revealed a potential relationship between the dynamic organization of channels in clusters and the termination of the regenerative feedback of Ca2+-induced Ca2+ release. Lastly, we consider how this information might impact on the development of new RyR-focused therapies.
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Williams et al. (2017) conducted a review in Ryanodine receptor function and structure. Ryanodine receptor (RyR) structure and organization was evaluated. Recent advances in ryanodine receptor structure and dynamic organization provide new insights into channel gating mechanisms and potential targets for RyR-focused therapies.
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