Key result
Structural biology studies using cryo-electron microscopy, NMR, and X-ray crystallography reveal that ryanodine receptors form massive mushroom-shaped allosteric ion channels.
Design
Review
Authors
Loading...
RyR structural details advance allosteric models of Ca2+ release; leaves open translation to arrhythmia or HF therapies.
This review summarizes the structural biology of ryanodine receptors, highlighting their complex architecture and allosteric mechanisms crucial for excitation-contraction coupling in muscle cells.
Kimlicka et al. (2011) conducted a review in Ryanodine receptor structure and function. Structural biology studies using cryo-electron microscopy, NMR, and X-ray crystallography reveal that ryanodine receptors form massive mushroom-shaped allosteric ion channels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: