Key result
Recent structural studies of Ryanodine and IP3 receptors provide functional insights that will aid in the development of rationale treatments for Ca(2+)-signaled malignancies.
Design
Review
Authors
Loading...
May inform rational drug design for Ca(2+)-signaled cancers; leaves open clinical translation pending functional validation.
High-resolution structural mapping of Ryanodine receptors provides foundational insights into the mechanisms of skeletal and cardiomyocyte diseases caused by channel mutations.
Amador et al. (2013) conducted a review in Skeletal or cardiomyocyte disease. Recent structural studies of Ryanodine and IP3 receptors provide functional insights that will aid in the development of rationale treatments for Ca(2+)-signaled malignancies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: