Key result
High-resolution structural studies of ryanodine and IP3 receptors clarify channel regulation and disease mutations.
Why the study?
Many questions remain regarding the structural effects of posttranslational modifications, additional binding partners, and higher-order complexes formed in situ by Ca2+-release channels.
Design
Review
Authors
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High-resolution structures may guide Ca2+ channel modulator design; extends mechanistic models but leaves open clinical translation.
Key points are not available for this paper at this time.
Woll et al. (2021) reported a review. Recent structural studies of ryanodine and IP3 receptors near 3 Å resolution provide mechanistic insights into channel regulation, auxiliary protein binding, and disease-associated mutations.
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