Key result
Review details the mechanisms by which diverse pharmacological agents modify intracellular calcium release channels.
Why the study?
Intracellular Ca(2+) release channels have important pathophysiological roles in cardiac arrhythmias and heart failure, motivating the identification of novel selective pharmacological regulators.
Population
Intracellular Ca(2+) release channels including IP(3)Rs and RyRs
Comparison
Pharmacological agents interacting directly with intracellular Ca(2+) release channels
Design
Review article
Authors
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May implicate IP3Rs and RyRs in disease; leaves open therapeutic targeting pending validation.
This review provides a comprehensive overview of pharmacological regulators of intracellular calcium release channels, highlighting their potential relevance in treating cardiac arrhythmias and heart failure.
West et al. (2007) reported a review. Pharmacological regulators of intracellular calcium release channels was evaluated. This review describes the wide array of pharmacological agents that interact directly with intracellular calcium release channels and their mechanisms of modifying channel function.
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