Key result
Subcellular Ca2+ signaling in the heart is regulated by Ca2+-induced Ca2+ release, which is centrally influenced by RYR2 sensitivity to intracellular Ca2+ concentration.
This review outlines the mechanisms of RYR2 sensitivity in cardiac Ca2+ signaling and its role in dystrophic cardiomyopathy.
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Refines cardiac Ca2+ handling models; leaves open whether CICR sensitivity modulation affects clinical arrhythmia risk.
Prosser et al. (2010) conducted a review in Dystrophic cardiomyopathy. Subcellular Ca2+ signaling in the heart is regulated by Ca2+-induced Ca2+ release, which is centrally influenced by RYR2 sensitivity to intracellular Ca2+ concentration.
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