Direct Modulation of RyR2 Leading to a TRICky Ca 2+ Balance

Q: What is the clinical evidence from this study?

Study design: Review. Population: Heart failure and arrhythmias.

Q: What does this research mean for the field?

Regulation of sarcoplasmic reticulum Ca2+ release and store overload-induced Ca2+ release (SOICR) through RyR2 is critical for mitigating defective Ca2+ cycling and arrhythmogenesis in heart failure. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Luis Alberto Gonano; Martín Vila Petroff

doi:10.1161/circresaha.120.316532

February 13, 2020Circulation ResearchOpen Access

Direct Modulation of RyR2 Leading to a TRICky Ca 2+ Balance

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Population

Heart failure and arrhythmias

Implication

Understanding the mechanisms regulating SR Ca2+ release and SOICR is critical for addressing defective Ca2+ cycling in heart failure and arrhythmias.

Abstract

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Cite This Study

Gonano et al. (2020) conducted a review in Heart failure and arrhythmias.

synapsesocial.com/papers/6ab0a5d556764d25c325d89a https://doi.org/10.1161/circresaha.120.316532

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Direct Modulation of RyR2 Leading to a TRICky Ca 2+ Balance

PICO

Implication

Abstract

Discussion

Cite This Study

Direct Modulation of RyR2 Leading to a TRICky Ca 2+ Balance

PICO

Implication

Abstract

Discussion

Cite This Study

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