Key result
ACE inhibitor use in children with chronic kidney disease was associated with an 89% higher likelihood of having a normal ambulatory blood pressure (OR 1.89; 95% CI 1.17-3.04).
Population
332 children with chronic kidney disease evaluated 1 year after entry in the Chronic Kidney Disease in…
Design
Cohort
Follow-up
1 year after entry
Authors
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Supports hypothesis of benefit in pediatric CKD; hypothesis-generating and requires RCTs before practice change.
Cohort (n=332)
Odds Ratio: 1.89 (95% CI 1.17–3.04)
Abnormalities on ABPM, particularly masked hypertension, are highly prevalent in children with CKD and are associated with risk factors for end-stage renal disease, highlighting the importance of routine ABPM in this population.
Samuels et al. (2012) conducted a cohort in chronic kidney disease (n=332). Angiotensin-converting enzyme inhibitor use vs. No angiotensin-converting enzyme inhibitor use was evaluated on Normal ambulatory blood pressure (OR 1.89, 95% CI 1.17-3.04). ACE inhibitor use in children with chronic kidney disease was associated with an 89% higher likelihood of having a normal ambulatory blood pressure (OR 1.89; 95% CI 1.17-3.04).
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