Key result
Postoperative ketorolac reduced patient-controlled morphine consumption by over 40% in the first 24 hours compared to placebo, with no evidence of cardiorespiratory depression.
Why the study?
Does parenteral ketorolac provide effective analgesia without cardiorespiratory depression in perioperative patients compared to opioids or placebo?
Population
Perioperative patients (including those undergoing upper abdominal surgery)
Comparison
Parenteral ketorolac vs Alfentanil or placebo
Design
Review
Follow-up
24 hours postoperatively
Authors
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Ketorolac may support opioid-sparing perioperative analgesia without cardiorespiratory effects; leaves open confirmation in randomized trials.
RCT
Does parenteral ketorolac provide effective analgesia without cardiorespiratory depression in perioperative patients compared to opioids or placebo?
Parenteral ketorolac provides effective perioperative analgesia with a significant opioid-sparing effect and no associated cardiorespiratory depression.
Kenny et al. (1990) conducted an RCT in Perioperative pain. Ketorolac vs. Alfentanil and Placebo was evaluated on Morphine consumption and cardiorespiratory function. Postoperative ketorolac reduced patient-controlled morphine consumption by over 40% in the first 24 hours compared to placebo, with no evidence of cardiorespiratory depression.
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