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May 1, 1993Anesthesia & Analgesia

Effects of Ketorolac on Postoperative Analgesia and Ventilatory Function After Laparoscopic Cholecystectomy

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Why the study?

Does ketorolac reduce postoperative pain requiring fentanyl in patients undergoing laparoscopic cholecystectomy?

Population

60 patients undergoing laparoscopic cholecystectomy

Comparison

Ketorolac 60 mg administered 20-40 min before… vs Placebo administered 20-40 min before surgery…

Design

RCT, assigned randomly, double-blind protocol

Follow-up

up to the following morning

Authors

JLJin LiuSun Yat-sen UniversityYDYifeng DingU.S. National Science FoundationPWPaul F. WhiteForest Institute

Discussion

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Implication

Supports ketorolac incorporation into multimodal regimens to cut fentanyl needs after laparoscopic cholecystectomy; extends opioid-sparing evidence to this population.

Structured PICO

Does ketorolac reduce postoperative pain requiring fentanyl in patients undergoing laparoscopic cholecystectomy?

P
Population
60 patients undergoing laparoscopic cholecystectomy
I
Intervention
Ketorolac 60 mg administered 20-40 min before surgery and a second 60 mg dose 4 h after the initial dose
C
Comparator
Placebo (saline) administered 20-40 min before surgery and a second dose 4 h after the initial dose
O
Outcome
Postoperative pain requiring treatment with fentanylpatient reported

Ketorolac significantly decreases the postoperative requirement for opioid analgesic medication after laparoscopic cholecystectomy.

Cite This Study

Liu et al. (1993) studied this question.

synapsesocial.com/papers/6a7da4168e0d8773fb3c9067https://doi.org/10.1213/00000539-199305000-00026
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