Key result
Premedication with 1g intravenous paracetamol resulted in similar intraoperative remifentanil consumption (0.0739 vs 0.0741 µg/kg/min) and postoperative analgesic needs compared to 30mg intravenous ketorolac.
RCT (n=100)
Randomly assigned
No
Absolute Event Rate: 0.0739% vs 0.0741%
p-value: p=0.954
IV paracetamol premedication yields similar reductions in anesthetic and opioid needs as ketorolac; leaves open preferred agent pending larger trials.
Objective: To compare the effects of premedication with intravenous paracetamol versus ketorolac, in decreasing intraoperative anesthetic and postoperative opioid analgesics requirements in patients undergoing laparoscopic cholecystectomy.
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Adrián José Medina Vera (2016) conducted an RCT in Laparoscopic cholecystectomy (n=100). Paracetamol vs. Ketorolac 30mg intravenous was evaluated on Intraoperative remifentanil consumption (µg/kg/min) (p=0.954). Premedication with 1g intravenous paracetamol resulted in similar intraoperative remifentanil consumption (0.0739 vs 0.0741 µg/kg/min) and postoperative analgesic needs compared to 30mg intravenous ketorolac.
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