September 1, 1988Anesthesiology
Calcium Channel Blockade Does Not Offer Adequate Protection from Perioperative Myocardial Ischemia
Key result
Calcium entry blocking drugs alone were associated with a significantly higher incidence of perioperative ischemic ECG changes during CABG compared to beta-blockers alone or in combination.
Why the study?
Does treatment with calcium entry blocking drugs alone prevent perioperative myocardial ischemia in patients undergoing coronary bypass grafting compared to beta-blockers or combination therapy?
Population
Patients undergoing coronary bypass grafting
Comparison
Calcium entry blocking drugs alone vs Beta-adrenergic blocking drugs alone or in…
Design
Cohort
Follow-up
Prebypass period (perioperative)
Authors
Discussion
Loading...
Member takes
Implication
May warrant avoiding calcium channel blockers alone perioperatively in CABG; leaves open optimal regimens for randomized confirmation.
Study Design
Type
Observational
Structured PICO
Does treatment with calcium entry blocking drugs alone prevent perioperative myocardial ischemia in patients undergoing coronary bypass grafting compared to beta-blockers or combination therapy?
P
Population
Patients undergoing coronary bypass grafting receiving beta-adrenergic blocking drugs, calcium entry blocking drugs, or both.
E
Exposure
Calcium entry blocking drugs alone
C
Comparator
Beta-adrenergic blocking drugs alone or in combination with calcium channel blocking drugs
O
Outcome
Electrocardiographic evidence of myocardial ischemia during the prebypass period (at induction of anesthesia, skin incision, and sternotomy)surrogate
Main Result
p-value: p=<0.03, <0.05, <0.002
Calcium channel blockers alone are less effective than beta-blockers or combination therapy in preventing perioperative myocardial ischemia during coronary bypass grafting.
Cite This Study
Chung et al. (1988) conducted an observational in Coronary bypass grafting. Calcium entry blocking drugs alone vs. Beta-adrenergic blocking drugs alone or in combination with calcium entry blocking drugs was evaluated on Electrocardiographic evidence of myocardial ischemia during the prebypass period (p=<0.03, <0.05, <0.002). Calcium entry blocking drugs alone were associated with a significantly higher incidence of perioperative ischemic ECG changes during CABG compared to beta-blockers alone or in combination.