Divergent sequences in the 5′ region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations
Key result
Analysis of two partially overlapping cDNAs suggests that mitochondrial, peroxisomal, and possibly endoplasmic reticulum carnitine acetyltransferase mRNAs derive from alternative splicing.
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Discussion
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Implication
Suggests alternative splicing enables subcellular targeting of carnitine acetyltransferase; leaves open its relevance to cardiac metabolism.
Key Points
Key points are not available for this paper at this time.
Cite This Study
Corti et al. (1994) studied this question. Analysis of two partially overlapping cDNAs suggests that mitochondrial, peroxisomal, and possibly endoplasmic reticulum carnitine acetyltransferase mRNAs derive from alternative splicing.