Key result
Patient-specific FSI simulations showed strong correlation with 4D-Flow MRI for flow waveforms in the ascending aorta, coarctation, and descending aorta (R2 0.97, 0.84, and 0.81, respectively).
Why the study?
The agreement between patient-specific CFD simulations and clinical standard 4D-Flow MRI in patients with aortic coarctation needed to be characterized.
Does patient-specific CFD FSI simulation agree with 4D-Flow MRI in quantifying hemodynamics in patients with aortic coarctation?
Observational (n=5)
Does patient-specific CFD FSI simulation agree with 4D-Flow MRI in quantifying hemodynamics in patients with aortic coarctation?
Effect estimate: R2 0.97, 0.84, and 0.81
Patient-specific fluid-structure interaction simulations show strong correlation with in vivo 4D-Flow MRI for quantifying hemodynamics in aortic coarctation, offering a potential alternative for treatment planning.
May support CFD-MRI integration for CoA hemodynamics assessment; leaves open standardization and clinical adoption.
The analysis of quantitative hemodynamics provides information for the diagnosis and treatment planning in patients with aortic coarctation (CoA). Patient-specific computational fluid dynamics (CFD) simulations reveal detailed hemodynamic information, but their agreement with the clinical standard 4D-Flow magnetic resonance imaging (MRI) needs to be characterized. This work directly compares in vivo CFD fluid-structure interaction (FSI) simulations against 4D-Flow MRI in patients with CoA (N=5). 4D-Flow MRI-derived flow waveforms and cuff blood pressure measurements were used to tune the boundary conditions for the FSI simulations. Flow rates from 4D-Flow MRI and FSI were compared at cross-sections in the ascending aorta (AAo), CoA and descending aorta (DAo). Qualitative comparisons showed an overall agreement of flow patterns in the aorta between the two methods. The R 2 values for the flow waveforms in the AAo, CoA, and DAo were 0.97, 0.84 and 0.81 respectively, representing a strong correlation between 4DFlow MRI measurements and FSI results. This work characterizes the use of patient-specific FSI simulations in quantifying and analyzing CoA hemodynamics to inform CoA treatment planning.
No takes yet. Share an insight, caveat, or question.
Nair et al. (2023) conducted an observational in Aortic coarctation (n=5). Fluid-structure interaction (FSI) simulation vs. 4D-Flow MRI was evaluated on Correlation of flow waveforms between FSI and 4D-Flow MRI in the ascending aorta, coarctation, and descending aorta (R2 0.97, 0.84, and 0.81). Patient-specific FSI simulations showed strong correlation with 4D-Flow MRI for flow waveforms in the ascending aorta, coarctation, and descending aorta (R2 0.97, 0.84, and 0.81, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: