Key result
Taohong Siwu decoction effectively reduced platelet adhesion and aggregation in normal rats and significantly reduced plasma TXB2, VWF, and GMP-140 levels in blood stasis rats.
Why the study?
Does Taohong Siwu decoction reduce platelet activation in rat models?
Does Taohong Siwu decoction reduce platelet activation in rat models?
Taohong Siwu decoction demonstrates anti-platelet activation effects in rat models, suggesting potential mechanisms for its use in treating blood stasis.
Should not yet change practice; leaves open antiplatelet effects for human translation and trials.
OBJECTIVE: To explore the anti-platelet activation effect and partial mechanisms of Taohong Siwu decoction (TSD). METHOD: The effect to venous thrombosis model and pulmonary thromboembolism model induced by vein injecting ADP and Adr was observed. The platelet adhesion rate was analyzed by using spinning glass bottle, and the platelet aggregation rate induced by ADP, Adr was analyzed by using turbidimetry. The acute blood stasis rat model was established to analyze the content of plasm TXB2 and PGI2 by RIA, and the content of VWF, GMP-14 by ELISA. RESULT: TSD could effectively reduce platelet the adhesion rate of normal rat, inhibit the platelet aggregation of normal rat induced by ADP, Adr. It significantly reduced the plasma TXB2 VWF, and GMP-140 level of blood stasis rats. It also had significant tendency to increase 6-keto-PGF1alpha level. CONCLUSION: TSD possessed obvious activity of inhibiting platelet activation. The mechanism related with the restraining of platelet adhesion, platelet aggregation and platelet releasion.
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Lan Han (2010) studied Venous thrombosis, pulmonary thromboembolism, and acute blood stasis (rat models). Taohong Siwu decoction (TSD) was evaluated on Platelet adhesion rate, platelet aggregation rate, and plasma levels of TXB2, PGI2, VWF, and GMP-14. Taohong Siwu decoction effectively reduced platelet adhesion and aggregation in normal rats and significantly reduced plasma TXB2, VWF, and GMP-140 levels in blood stasis rats.
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