Key result
Several Traditional Chinese Medicine extracts demonstrate in vitro anti-platelet aggregation matching or exceeding aspirin.
Why the study?
The anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines with blood-activating and stasis-resolving properties were not well evaluated in vitro.
Do extracts from 31 Traditional Chinese Medicines inhibit platelet aggregation in vitro compared to aspirin?
Do extracts from 31 Traditional Chinese Medicines inhibit platelet aggregation in vitro compared to aspirin?
In vitro testing suggests that extracts from certain Traditional Chinese Medicines, including Chuanxiong, Yanhusuo, and Danshen, possess anti-platelet aggregation properties comparable to aspirin.
Should not yet inform clinical practice; leaves open potential for TCM extracts as antiplatelet therapies pending in vivo and human validation.
OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines (TCM) with the property of activating blood and resolving stasis in terms of TCM theory. METHODS: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachidonic acid (AA) as aggregation inducers, respectively. Aspirin was the positive control. RESULTS: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various agonists. Especially, some of the TCMs such as Chuanxiong (Rhizoma Chuanxiong), Yanhusuo (Rhizoma Corydalis Yanhusuo) and Danshen (Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control group. CONCLUSION: The study provided scientific references that several TCMs such as Chuanxiong (Rhizoma Chuanxiong), Yanhusuo (Rhizoma Corydalis Yanhusuo) and Danshen (Radix Salviae Miltiorrhizae), possess the property of anti-platelet aggregation.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2017) studied Platelet aggregation. Extracts from 31 Traditional Chinese Medicines vs. Aspirin was evaluated on Anti-platelet aggregation effect in vitro. Extracts from several Traditional Chinese Medicines (e.g., Chuanxiong, Yanhusuo, Danshen) demonstrated concentration-dependent anti-platelet aggregation effects similar to or higher than aspirin.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: