Key result
Drug therapies for heart failure are analyzed based on their molecular mechanisms and specific targets, highlighting current treatments and future perspectives.
Why the study?
Characterizing disease progression, symptoms, and the underlying mechanisms of heart failure is vital to optimize and guide drug therapy selection.
This review summarizes the molecular mechanisms of heart failure and current/future drug therapies targeting specific pathways.
May guide mechanistic HF drug selection; leaves open prospective validation of novel targets before practice change.
Heart failure (HF) is a complex clinical syndrome that results from left ventricular myocardial dysfunction and contributes to dyspnea, fatigue and fluid retention. It's essential to characterize disease progression and symptoms to optimize therapy selection. Also, understanding the mechanisms of HF to guide therapy selection is of vital importance. This review focuses on the demonstrating mechanisms of HF and points out the possible pathways involved in the process. Drug therapies of HF with different effects on specific targets are analyzed. Finally, we conclude the features of the now going drugs and depict the future perspectives of drug therapy of HF, including potential new targets and new drug therapies.
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A 2020 study conducted a review in Heart failure. Drug therapies was evaluated. Drug therapies for heart failure are analyzed based on their molecular mechanisms and specific targets, highlighting current treatments and future perspectives.
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