Key result
Proteinuria and moderate-to-severe eGFR impairment were associated with increased arterial stiffness, while only proteinuria was associated with abnormal central hemodynamics.
Why the study?
Do moderate-to-severe eGFR impairment and proteinuria alter central hemodynamics and increase arterial stiffness in healthy middle-aged men?
Cross-Sectional (n=2,244)
Do moderate-to-severe eGFR impairment and proteinuria alter central hemodynamics and increase arterial stiffness in healthy middle-aged men?
Proteinuria is an independent risk factor for both abnormal central hemodynamics and increased arterial stiffness, while moderate-to-severe eGFR impairment is associated only with increased arterial stiffness in healthy middle-aged men.
No takes yet. Share an insight, caveat, or question.
Findings should not yet change practice; hypothesis-generating for proteinuria and eGFR links to arterial stiffness and hemodynamics.
Tomiyama et al. (2011) conducted a cross-sectional in Healthy (n=2,244). Moderate-to-severe impairment of eGFR and proteinuria vs. Absence of moderate-to-severe impairment of eGFR and proteinuria was evaluated on Central hemodynamics (radial augmentation index) and pulse wave velocity (brachial-ankle PWV). Proteinuria and moderate-to-severe eGFR impairment were associated with increased arterial stiffness, while only proteinuria was associated with abnormal central hemodynamics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: