Key result
Estimated glomerular filtration rate exhibited a non-linear relationship with arterial stiffness, showing a significant negative association with brachial-ankle pulse wave velocity (β = -2.80) only when eGFR was below 77.05.
Why the study?
Is estimated glomerular filtration rate (eGFR) associated with arterial stiffness (baPWV) in a Japanese population?
Cross-Sectional (n=912)
No
Is estimated glomerular filtration rate (eGFR) associated with arterial stiffness (baPWV) in a Japanese population?
Mean Difference: -2.8 (95% CI -4.41–-1.19)
p-value: p=0.007
There is a non-linear relationship between eGFR and arterial stiffness (baPWV) in a Japanese population, with a significant negative association observed when eGFR is below 77.05.
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Nonlinear eGFR-baPWV association below 77 warrants caution in low-eGFR patients; leaves open prospective validation before clinical use.
Yun-fen et al. (2019) conducted a cross-sectional in General population undergoing health check-up (n=912). Estimated glomerular filtration rate (eGFR) vs. Higher eGFR levels (>77.05 mL/min/1.73 m2) was evaluated on Brachial-ankle pulse wave velocity (baPWV) (β = -2.80, 95% CI -4.41 to -1.19, p=0.007). Estimated glomerular filtration rate exhibited a non-linear relationship with arterial stiffness, showing a significant negative association with brachial-ankle pulse wave velocity (β = -2.80) only when eGFR was below 77.05.
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