What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Obesity and Essential Hypertension (n=246). Intervention: Obesity and/or hypertension vs. Normal weight, normotensive subjects. Primary outcome: Serum CTRP3 levels (p=<0.001).

April 9, 2015Diabetology & Metabolic SyndromeOpen Access

Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance

Q: What are the key findings of this study?

Serum CTRP3 levels were significantly lower in obese subjects compared to normal weight subjects (94.53 vs 116.84 ng/ml) and were independently associated with diastolic blood pressure and insulin resistance.

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Key result

Serum CTRP3 levels were significantly lower in obese subjects compared to normal weight subjects (94.53 vs 116.84 ng/ml) and were independently associated with diastolic blood pressure and insulin resistance.

Population

246 Chinese adults including 180 newly diagnosed obese and/or essential hypertensive patients and 66 normal…

Design

Cross-sectional

Authors

WDWuquan DengChongqing University CLChangyan LiAnhui Medical University YZYuping ZhangUniversity of Michigan

Discussion

Member takes

Implication

CTRP3 may reflect IR and inflammation in obese hypertensives; leaves open biomarker or causal role pending prospective data.

Study Design

Type

Cross-Sectional (n=246)

Multicenter

Structured PICO

Population

246 Chinese adults aged 20 to 65 years, including newly diagnosed obese and hypertensive patients and normal weight normotensive controls, evaluated for serum CTRP3 levels.

Outcome

Serum CTRP3 levels and their correlation with anthropometric, inflammatory, and metabolic parameters (including insulin resistance)surrogate

Main Result

Absolute Event Rate: 94.53% vs 116.84%

p-value: p=<0.001

Serum CTRP3 levels are significantly decreased in newly diagnosed obese and hypertensive patients and are independently associated with diastolic blood pressure and insulin resistance.

Limitations

Small sample size of men and women of Chinese ethnicity, limiting generalizability to other ethnicities
Cross-sectional analysis restricts the ability to draw causal conclusions
Did not perform oral glucose tolerance tests or glucose clamp studies to determine insulin resistance
Small sample size of Chinese ethnicity, limiting generalizability
Cross-sectional design restricts ability to draw causal conclusions
Lack of oral glucose tolerance tests or glucose clamp studies to determine insulin resistance

Cite This Study

Deng et al. (2015) conducted a cross-sectional in Obesity and Essential Hypertension (n=246). Obesity and/or hypertension vs. Normal weight, normotensive subjects was evaluated on Serum CTRP3 levels (p=<0.001). Serum CTRP3 levels were significantly lower in obese subjects compared to normal weight subjects (94.53 vs 116.84 ng/ml) and were independently associated with diastolic blood pressure and insulin resistance.

synapsesocial.com/papers/6a9802d38818801a6fe1882e https://doi.org/10.1186/s13098-015-0029-0

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Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider