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December 29, 2016PLoS ONEOpen Access

Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus

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Population

172 subjects aged 45-75 years who underwent coronary angiography, categorized into four groups: Group I…

Design

Case-control

Authors

RFReza FadaeiNMNariman MoradiMBMehdi Baratchian

Discussion

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Overview

May refine CAD risk models in observational data; leaves open causality and interventional potential.

Structured PICO

P
Population
172 subjects aged 45-75 years who underwent coronary angiography, categorized into four groups: Group I (without T2DM and CAD, n=43), Group II (with CAD but no T2DM, n=43), Group III (with T2DM but no CAD, n=43), and Group IV (with T2DM and CAD, n=43).
O
Outcome
Association of CTRP3 and CTRP13 serum levels and gene expression with the presence of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM)surrogate

Decreased serum levels of CTRP3 and CTRP13 are associated with an increased risk of T2DM and CAD, suggesting a potential role for these adipokines in CAD pathogenesis.

Cite This Study

Fadaei et al. (2016) studied this question.

synapsesocial.com/papers/6a832e4d88eff2bd7befecf4https://doi.org/10.1371/journal.pone.0168773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance2015 · 78 citations
  2. 2Association of Circulating C1q/TNF-Related Protein 1 Levels with Coronary Artery Disease in Men2014 · 45 citations
  3. 3C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart2012 · 180 citations
  4. 4Circulating Level of CTRP1 in Patients with Nonalcoholic Fatty Liver Disease (NAFLD): Is It through Insulin Resistance?2015 · 34 citations
  5. 5Role of adipokines in cardiovascular disease2012 · 292 citations