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January 30, 2018PLoS ONEOpen Access

Serum CTRP9 concentration was independently associated with the increased risk of CAD (OR 1.018, 95% CI 1.009–1.026, p < 0.001) and T2DM (OR 1.015, 95% CI 1.005–1.025, p = 0.003) after adjustment for age, sex, BMI, adiponectin, IL-6 and TNF-α.

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Population

337 adults aged 45-75 years who underwent coronary angiography, categorized into control, CAD, T2DM, and…

Design

Case-control

Authors

NMNariman MoradiRFReza FadaeiSESolaleh Emamgholipour

Discussion

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Overview

CTRP9 merits evaluation as a biomarker for CAD and T2DM; observational data leave open causality and clinical utility.

Structured PICO

P
Population
337 adults aged 45-75 years who underwent coronary angiography, categorized into control (n=80), CAD (n=157), T2DM (n=37), and CAD+T2DM (n=63). Exclusions included acute coronary syndrome, history of stroke, myocardial infarction, kidney disease, cancer, autoimmune disease, chronic inflammation, and thiazolidinedione use.
O
Outcome
Association of serum CTRP9 levels with the presence of CAD and T2DM, and correlation with soluble adhesion molecules (sICAM-1, sVCAM-1, sE-Selectin) and inflammatory markers (IL-6, TNF-α)surrogate

Limitations

  • relatively small sample size, especially in the T2DM group
  • case-control study design in which the cause-and-effect relationship could not be determined

Cite This Study

Moradi et al. (2018) studied this question.

synapsesocial.com/papers/6a832e4d88eff2bd7befecf2https://doi.org/10.1371/journal.pone.0192159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans2015 · 53 citations
  2. 2Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction2016 · 25 citations
  3. 3Association between circulating CTRP9 levels and coronary artery disease: a systematic review and meta-analysis2024 · 4 citations
  4. 4Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus2016 · 71 citations
  5. 5Higher serum level of CTRP15 in patients with coronary artery disease is associated with disease severity, body mass index and insulin resistance2019 · 27 citations