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January 1, 2016Journal of Diabetes ResearchOpen Access

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction

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Key result

Higher plasma CTRP9 linked to increased carotid IMT in T2D patients without chronic kidney disease.

  • n=419

Why the study?

Are plasma CTRP9 levels associated with carotid intima-media thickness in patients with type 2 diabetes?

Population

419 patients with type 2 diabetes, including 161 with chronic kidney disease (CKD)

Design

Cross-sectional

Authors

MAMariko AsadaTMTomoaki MoriokaYYYuko Yamazaki

Discussion

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Overview

CTRP9 measurement should not yet inform T2D management; leaves open its role as atherosclerosis biomarker pending longitudinal studies.

Study Design

Type

Observational (n=419)

Structured PICO

Are plasma CTRP9 levels associated with carotid intima-media thickness in patients with type 2 diabetes?

P
Population
419 patients with type 2 diabetes, including 161 with chronic kidney disease, assessed for the association between plasma CTRP9 levels and carotid intima-media thickness.
E
Exposure
Plasma C1q/tumor necrosis factor-related protein-9 (CTRP9) levels
O
Outcome
Carotid intima-media thickness (IMT) measured with ultrasonographysurrogate

Plasma CTRP9 levels are independently associated with atherosclerosis progression (measured by carotid IMT) in patients with type 2 diabetes without chronic kidney disease.

Cite This Study

Asada et al. (2016) conducted an observational in Type 2 diabetes (n=419). Plasma CTRP9 levels was evaluated on Carotid intima-media thickness (IMT). Plasma CTRP9 levels were positively associated with carotid intima-media thickness in type 2 diabetes patients without chronic kidney disease, independent of traditional cardiovascular risk factors.

synapsesocial.com/papers/6aa648274dd50f8a0764c1f8https://doi.org/10.1155/2016/8624313
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease2018 · 58 citations
  2. 2Association of Serum C1q/TNF-Related Protein-9 Concentration With Arterial Stiffness in Subjects With Type 2 Diabetes2014 · 46 citations
  3. 3Association of serum CTRP9 levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus2021 · 6 citations
  4. 4The CTRP5  Circulating Levels  and the Ratio of CTRP1 to CTRP5 in Plasma are Significant Predictors for Carotid Intima-Media Thickness(cIMT) value in Patients with type 2 diabetes: A Preliminary Study2020 · 1 citations
  5. 5The Circulating Levels of CTRP1 and  CTRP5  Are Associated with Obesity Indices and  Carotid Intima-Media Thickness (cIMT) Value in Patients with Type 2 Diabetes: A Preliminary Study2021