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November 18, 2024PeerJOpen Access

Association between circulating CTRP9 levels and coronary artery disease: a systematic review and meta-analysis

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Key result

Circulating CTRP9 levels are significantly lower in patients with CAD versus those without.

  • P=0.001

Why the study?

Studies have reported conflicting results regarding circulating CTRP9 levels in patients with and without coronary artery disease.

Are circulating CTRP9 levels associated with coronary artery disease?

Population

Patients across 25 included articles

Comparison

CAD patients vs patients without CAD

Design

Systematic review and meta-analysis

Authors

ZZZiyi ZhuSir Run Run Shaw HospitalQNQingsheng NiuSichuan UniversitySTShiyuan TangTianjin University of Traditional Chinese Medicine

Discussion

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Overview

May support CTRP9 as CAD biomarker; hypothesis-generating and needs prospective validation before clinical adoption.

Study Design

Type

Meta-Analysis

Structured PICO

Are circulating CTRP9 levels associated with coronary artery disease?

P
Population
Patients with and without coronary artery disease (CAD) from 25 included articles
I
Intervention
Circulating C1q tumor necrosis factor (TNF) related proteins 9 (CTRP9) levels
C
Comparator
Patients without CAD
O
Outcome
Difference in circulating CTRP9 levels between patients with and without CADsurrogate

Main Result

p-value: p== 0.001

Circulating CTRP9 levels are significantly lower in patients with coronary artery disease compared to those without, suggesting a potential role as a biomarker.

Limitations

  • High heterogeneity

Cite This Study

Zhu et al. (2024) conducted a meta-analysis in Coronary artery disease. Circulating CTRP9 levels vs. Patients without CAD was evaluated on Circulating CTRP9 levels (p== 0.001). Circulating CTRP9 levels in patients with coronary artery disease were significantly lower than those in patients without CAD (P=0.001).

synapsesocial.com/papers/6a0fed08b6f5ee0401601a14https://doi.org/10.7717/peerj.18488

Topics

Coronary artery disease
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