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December 8, 2014Practical Neurology

Management of orthostatic hypotension in patients with Parkinson's disease

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Population

Patients with Parkinson's disease experiencing orthostatic hypotension

Design

Review

Key result

General measures followed by medications with low risk of severe adverse effects are the recommended management for orthostatic hypotension in Parkinson's disease.

Authors

CWConnie WuAHAnna DePold Hohler

Discussion

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Overview

Endorses stepwise conservative management for orthostatic hypotension in Parkinson's disease; leaves open need for RCTs to optimize drug selection.

Structured PICO

P
Population
Patients with Parkinson's disease experiencing orthostatic hypotension
I
Intervention
General measures followed by medications

Current recommendations for orthostatic hypotension in Parkinson's disease prioritize general measures before pharmacological interventions.

Cite This Study

Wu et al. (2014) studied this question. General measures followed by medications with low risk of severe adverse effects are the recommended management for orthostatic hypotension in Parkinson's disease.

synapsesocial.com/papers/6a98040f0fc5fb4479fae175https://doi.org/10.1136/practneurol-2014-001000
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Midodrine vs Placebo in Neurogenic Orthostatic Hypotension1997 · 429 citations
  2. 2Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome2004 · 84 citations
  3. 3Mineralocorticoid-Induced Hypertension in Patients with Orthostatic Hypotension1979 · 220 citations
  4. 4Oral yohimbine in human autonomic failure1987 · 86 citations
  5. 5Domperidone and Long QT Syndrome2010 · 88 citations