Key result
DeltaACT-LR detected excessive anticoagulation with an AUC of 0.87 (95% CI 0.80-0.93), but poor correlation between ACT-LR and APTT does not support its routine use.
Why the study?
Does the Hemochron Jr II Signature ACT-LR test accurately detect excessive anticoagulation compared to APTT in patients post-vascular surgery?
Population
103 patients in the post-operative period of vascular surgery receiving low dose heparin therapy
Comparison
Bedside activated clotting time test for… vs Activated partial thromboplastin time (APTT)
Design
Cohort
Follow-up
post-operative period
Authors
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Caution against ACT-LR for low-dose heparin monitoring post-vascular surgery; leaves open whether refined thresholds improve APTT correlation in prospective cohorts.
Observational (n=103)
Does the Hemochron Jr II Signature ACT-LR test accurately detect excessive anticoagulation compared to APTT in patients post-vascular surgery?
Effect estimate: AUC 0.87 (95% CI 0.80-0.93)
The Hemochron Jr II Signature ACT-LR test shows poor correlation with APTT, not supporting its routine use for monitoring low-dose heparin in vascular surgery.
Racioppi et al. (2009) conducted an observational in Vascular surgery requiring low dose heparin therapy (n=103). ACT-LR (Hemochron Jr II Signature) vs. APTT was evaluated on Excessive anticoagulation (APTT more than twice normal) (AUC 0.87, 95% CI 0.80-0.93). DeltaACT-LR detected excessive anticoagulation with an AUC of 0.87 (95% CI 0.80-0.93), but poor correlation between ACT-LR and APTT does not support its routine use.
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