Why the study?
The study aimed to assess and compare the effectiveness of prophylactic infusions of ephedrine versus phenylephrine in maintaining arterial pressure during hysterectomies under sub-arachnoid block.
Does prophylactic infusion of phenylephrine compared to ephedrine prevent hypotension in pregnant patients undergoing hysterectomies under spinal anaesthesia?
Population
80 ASA Grade I and II patients undergoing elective hysterectomies under spinal anaesthesia
Comparison
Phenylephrine 15 micrograms/min vs ephedrine 1.5 mg/min prophylactic infusion
Design
Randomized clinical trial
Key result
Prophylactic infusion of phenylephrine resulted in significantly more patients not requiring additional vasopressors compared to ephedrine (65% vs 22.5%) during hysterectomies under spinal anaesthesia.
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Phenylephrine infusion may reduce rescue boluses versus ephedrine during spinal hysterectomy; extends RCT comparisons to non-obstetric gynecologic surgery.
RCT (n=80)
Study drugs prepared by uninvolved anaesthesiologist
Computer generated randomization table
No
Does prophylactic infusion of phenylephrine compared to ephedrine prevent hypotension in pregnant patients undergoing hysterectomies under spinal anaesthesia?
Absolute Event Rate: 65% vs 22.5%
p-value: p=0.0001
Prophylactic infusion of phenylephrine is more effective than ephedrine in maintaining arterial blood pressure and reducing the need for rescue vasopressor boluses during spinal anesthesia for hysterectomies.
A 2018 study conducted an RCT in Hypotension during spinal anaesthesia (n=80). Phenylephrine vs. Ephedrine 1.5 mg/min was evaluated on Without additional vasopressor requirement (p=0.0001). Prophylactic infusion of phenylephrine resulted in significantly more patients not requiring additional vasopressors compared to ephedrine (65% vs 22.5%) during hysterectomies under spinal anaesthesia.
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