What question did this study set out to answer?

To determine whether the free-living nematode Caenorhabditis elegans can serve as an efficient primary screening tool to discover novel anthelmintics against parasitic nematodes.

June 25, 2015Nature CommunicationsOpen Access

Caenorhabditis elegans is a useful model for anthelmintic discovery

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To determine whether the free-living nematode Caenorhabditis elegans can serve as an efficient primary screening tool to discover novel anthelmintics against parasitic nematodes.
Screened a chemical library of 67,012 compounds for nematicidal lethality using Caenorhabditis elegans.
Rescreened validated hits across two parasitic nematode species and two vertebrate safety models, consisting of HEK293 cells and zebrafish.
Performed forward genetic screens across 19 million C. elegans mutants to evaluate resistance generation and identify compound mechanisms of action.
Identified 30 structurally distinct anthelmintic lead molecules displaying cross-species efficacy against parasitic worms and negligible toxicity in vertebrate models.
Mapped the target of a nanomolar-potent, nematode-selective lead compound to complex II of the mitochondrial electron transport chain while profiling resistance mutational liability.

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Implication

High-throughput screening reveals 30 anthelmintic lead molecules using Caenorhabditis elegans, highlighting its value as a cost-effective drug discovery model.

Cite This Study

Burns et al. (2015) studied this question.

synapsesocial.com/papers/6a9808106949e6b2f7c62ca2 https://doi.org/10.1038/ncomms8485

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Implication

High-throughput screening reveals 30 anthelmintic lead molecules using Caenorhabditis elegans, highlighting its value as a cost-effective drug discovery model.

Caenorhabditis elegans is a useful model for anthelmintic discovery

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Discussion

Implication

Cite This Study

Caenorhabditis elegans is a useful model for anthelmintic discovery

Key Points

Discussion

Implication

Cite This Study

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