Key result
Type-II diabetes is associated with a prolonged mean pupil cycle time of 1101.24 ms compared to 941.51 ms in healthy controls, with the difference approaching statistical significance (p=0.057).
Why the study?
Does type-II diabetes mellitus prolong pupil cycle time compared to healthy controls?
Case-Control (n=100)
No
Does type-II diabetes mellitus prolong pupil cycle time compared to healthy controls?
Type II diabetes is associated with prolonged pupil cycle time, which correlates with the duration of diabetes and severity of retinopathy, suggesting its utility as a simple test for autonomic neuropathy.
Pupil cycle time may mark autonomic neuropathy in type 2 diabetes; hypothesis-generating and requires prospective validation before clinical use.
Purpose of the study is to compare the pupil cycle time(PCT) of patients with type-II diabetes and healthy control subjects.To analyse the effect of different variables like age, sex, blood sugar,diabetes duration on PCT.Methods- The study was conducted on known type-II diabetes patients attending retina clinic and non diabetic patients attending Eye OPD of Regional institute of medical sciences,Imphal for a period of 2 years. 100 individuals were taken,out of these 50 were diabetics and 50 non diabetics.PCT was measured by focussing a narrow horizontally aligned beam of fixed dimensions at the inferior part of pupil to initiate rhythmic cycles of contraction and relaxation,and the cycle time was measured in milliseconds with a hand held stop watch.Mean PCT of diabetics was compared with non diabetics and its correlation with different variables such as age, diabetes duration,sex,blood sugar was done .Results-Mean PCT of diabetic patients was prolonged as compared to non diabetics and also there was prolongation of PCT with increasing age and diabetes duration.Conclusion-Type II diabetes is associated with prolonged PCT,and it gets more prolonged with the duration of diabetes.PCT can be used as a fast and reliable clinic test to assess the amount of autonomic neuropathy affecting pupil of a diabetic patient.
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Kaur et al. (2014) conducted a case-control in Type-II diabetes mellitus (n=100). Type-II diabetes mellitus vs. Healthy control subjects was evaluated on Mean pupil cycle time (PCT) (p=0.057). Type-II diabetes is associated with a prolonged mean pupil cycle time of 1101.24 ms compared to 941.51 ms in healthy controls, with the difference approaching statistical significance (p=0.057).
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