Key result
Elevated serum cystatin C levels were independently associated with an increased risk of cerebral infarction (OR 1.021; P=0.001) and predicted the risk of recurrent stroke.
Why the study?
Does serum cystatin C level correlate with the risk, subtype, severity, and recurrence of cerebral infarction?
Case-Control (n=1,551)
Does serum cystatin C level correlate with the risk, subtype, severity, and recurrence of cerebral infarction?
Serum cystatin C is an independent risk factor for cerebral infarction and correlates with the large-artery atherosclerosis subtype and risk of recurrent stroke, but not with stroke severity.
Answers are grounded in this paper and cite their sources.
Cystatin C should not inform CI care or risk models yet; leaves open its prognostic value pending prospective validation.
This study investigated the correlation of serum cystatin C levels with cerebral infarction (CI) and different subtypes of CI, the severity of CI and the risk of recurrent CI. Totally 1017 patients with CI and 534 healthy controls were included, with clinical and biochemical characteristics documented and analyzed. The results showed serum cystatin C were 0.93 ± 0.21 mg/l and 1.19 ± 0.5 mg/l in control and CI, respectively (p < 0.001). The significant risk factors for CI were age (p < 0.001, OR = 1.048), presence of diabetes (p = 0.007, OR = 2.397), cystatin C (p = 0.001, OR = 1.021), uric acid (p = 0.017, OR = 4.226), and systolic blood pressure (p = 0.021, OR = 1.003). The risk of CI increased with cystatin C levels. Also, cystatin C levels were associated with different subtypes of CI, with large-artery atherosclerosis (LAA) subtype having the highest level of cystatin C. Moreover, cystatin C levels were significantly and positively correlated with Essen Stroke Risk Score (ESRS). The higher level of cystatin C the higher risk of recurrent stroke. In contrast, correlation between cystatin C levels and National Institute of Health stroke scale (NIHSS) score was not significant. In conclusion, cystatin C was an independent risk factor for CI. LAA subtype of CI was more closely related to increased cystatin C level. Furthermore, cystatin C levels predict risk of recurrent CI but not the severity of CI.
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Zeng et al. (2015) conducted a case-control in Cerebral infarction (n=1,551). Serum cystatin C vs. Healthy controls was evaluated on Cerebral infarction (OR 1.021, p=0.001). Elevated serum cystatin C levels were independently associated with an increased risk of cerebral infarction (OR 1.021; P=0.001) and predicted the risk of recurrent stroke.
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