Key result
In acute ischemic stroke patients with high hsCRP levels, higher Cystatin C concentrations (≥0.78 mg/L) were associated with a 2.48-fold increased risk of recurrent stroke.
Why the study?
This study explored the value of cystatin C (CysC) in predicting stroke recurrence in patients with acute ischemic stroke.
Does Cystatin C concentration predict stroke recurrence in patients with acute ischemic stroke?
Cohort (n=3,474)
Single-blind
Yes
Does Cystatin C concentration predict stroke recurrence in patients with acute ischemic stroke?
Higher Cystatin C concentrations improve the prediction and reclassification of stroke recurrence and vascular events in patients with acute ischemic stroke, particularly those with high inflammation (hsCRP).
Answers are grounded in this paper and cite their sources.
CysC may refine post-stroke risk stratification; leaves open whether it should guide secondary prevention.
BACKGROUND: This study explored the value of cystatin C (CysC) in predicting stroke recurrence in patients with acute ischemic stroke. METHODS AND Moreover, CysC may improve reclassification of stroke recurrence (net reclassification improvement [NRI] 42.9%, P=0.001; integrated discrimination improvement [IDI] 1.2%, P=0.001) and vascular events (NRI 35.8%, P=0.001; IDI 1.1%, P=0.004). CONCLUSIONS: In ischemic stroke patients with high hsCRP concentrations, higher CysC concentrations increased the risk of stroke recurrence and vascular events. This indicates that the predictive value of CysC on stroke recurrence may depend on the inflammation status of patients.
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Liu et al. (2020) conducted a cohort in Acute Ischemic Stroke (n=3,474). Higher Cystatin C concentration (≥0.78 mg/L) vs. Lower Cystatin C concentration (<0.78 mg/L) was evaluated on Stroke recurrence in patients with high inflammation status (hsCRP ≥4.8 ng/mL) (HR 2.48, 95% CI 1.37-4.51, p=0.003). In acute ischemic stroke patients with high hsCRP levels, higher Cystatin C concentrations (≥0.78 mg/L) were associated with a 2.48-fold increased risk of recurrent stroke.
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