Key result
Serum Cystatin C levels were significantly elevated in patients with acute ischemic stroke (mean 1.40 mg/L) compared to healthy controls (mean 0.82 mg/L, p<0.001).
Why the study?
Cystatin C is a risk factor for cardiovascular and cerebrovascular disease, but its association with acute ischemic stroke, stroke severity, and extra- and intracranial stenosis required detection.
Does serum Cystatin C level correlate with the presence of acute ischemic stroke, stroke severity, and carotid artery stenosis?
Case-Control (n=66)
No
Does serum Cystatin C level correlate with the presence of acute ischemic stroke, stroke severity, and carotid artery stenosis?
Absolute Event Rate: 1.4% vs 0.82%
p-value: p=<0.001
Serum Cystatin C is significantly elevated in acute ischemic stroke and correlates with stroke severity and the presence of high-grade extracranial carotid stenosis.
Serum CysC was associated with ischemic stroke severity and stenosis; hypothesis-generating and requires prospective validation before clinical use.
Stroke is the third leading cause of death in developed nations. Ultrasonography (US) of the carotid arteries is the modality of choice for diagnosis and monitoring of cases of atheromatous disease. Cystatin C (CysC) is a risk factor for cerebrovascular and cardiovascular disease. To detect the association of serum CysC levels with acute ischemic stroke, the correlation of its levels with stroke severity, and the association between CysC levels with extra- and intracranial stenosis. Case-control study was conducted on 66 subjects, 33 patients within the first week of stroke onset with age range from 40 to 75 years, and 33 control healthy subjects with matched age and sex. All subjects underwent complete neurological examination, Extra- and transcranial duplex, CT brain, routine laboratory work-up, and serum CysC. Serum CysC levels were significantly raised in patients with acute ischemic stroke compared to controls. CysC levels were higher in patients with extracranial stenosis than in those with intracranial stenosis. Moreover, extracranial stenosis > 50% has higher levels of CysC. Serum CysC level showed a significant correlation with National Institutes of Health Stroke Scale (NIHSS) and intima-media thickness (IMT). Serum CysC can be used as a marker for acute atherosclerotic ischemic stroke and stroke severity. High-grade extracranial stenosis has the highest level of CysC.
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Zaki et al. (2019) conducted a case-control in Acute ischemic stroke (n=66). Serum Cystatin C level vs. Healthy controls was evaluated on Serum Cystatin C levels in acute ischemic stroke patients compared to healthy controls (p=<0.001). Serum Cystatin C levels were significantly elevated in patients with acute ischemic stroke (mean 1.40 mg/L) compared to healthy controls (mean 0.82 mg/L, p<0.001).
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