Key result
Elevated serum cystatin C levels were independently associated with an increased incidence of hemodynamically significant aortic valve disease, with an OR of 1.15 per standard deviation increase.
Why the study?
Cystatin C may increase the risk of aortic stenosis, but limited studies have reported on this association.
Does elevated serum cystatin C level increase the risk of incident hemodynamically significant aortic stenosis in the general population?
Cohort (n=4,791)
Yes
Does elevated serum cystatin C level increase the risk of incident hemodynamically significant aortic stenosis in the general population?
Odds Ratio: 1.15 (95% CI 1.05–1.26)
p-value: p=0.002
Elevated serum cystatin C levels are independently associated with an increased long-term risk of developing hemodynamically significant aortic valve disease in the general population.
Cystatin C elevation was associated with higher aortic valve disease risk; hypothesis-generating for risk stratification and requires prospective validation.
BACKGROUND: Cystatin C (CysC) is a cysteine protease inhibitor involved in proteins catabolism and plays an essential role in human vascular pathophysiology. CysC may also increase the risk of aortic stenosis (AS), but limited studies have reported on this association. This study aimed to investigate if elevated serum CysC levels are associated with hemodynamically significant AS. METHODS: Serum CysC levels were estimated in 4,791 participants, samples were collected in 1990-1992. The study population was divided into quintile groups. Follow-up continued in 2011-2013 when participants returned for echocardiography examination. Incidence of aortic valve disease (AVD) was ascertained by Doppler echocardiography through the end of 2013. AVD defined in hemodynamic progression was assessed and classified as aortic sclerosis, mild stenosis, and moderate-to-severe stenosis. RESULTS: = 0.002). CONCLUSIONS: In this large population-based study, an increased serum CysC levels is independently associated with the incidence of hemodynamically significant AS. However, this association appears not to extend to patients with extremely high serum CysC levels and necessitate further investigation.
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Christopher et al. (2021) conducted a cohort in Aortic stenosis (n=4,791). Serum cystatin C levels vs. Lower serum cystatin C levels was evaluated on Incidence of aortic valve disease (aortic sclerosis, mild stenosis, and moderate-to-severe stenosis) (OR 1.15, 95% CI 1.05-1.26, p=0.002). Elevated serum cystatin C levels were independently associated with an increased incidence of hemodynamically significant aortic valve disease, with an OR of 1.15 per standard deviation increase.
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