Key result
Renal denervation reduces both office and daily blood pressure, does not depend on patient adherence, and is efficient in patients with uncontrolled hypertension even without drug therapy.
Why the study?
Following conflicting results from early and subsequent randomized trials, updated synthesis was needed on the efficacy, safety, and benefits of renal denervation across patient groups.
Does renal denervation reduce blood pressure in patients with resistant or uncontrolled hypertension?
Does renal denervation reduce blood pressure in patients with resistant or uncontrolled hypertension?
Renal denervation is an effective method for reducing blood pressure in patients with uncontrolled hypertension, independent of medication adherence.
May support renal denervation for uncontrolled hypertension independent of adherence; leaves open prospective randomized confirmation without background therapy.
Renal denervation (RDN) is a method of the sympathetic nervous system modulation which has been specifically developed for the treatment of resistant hypertension. Initial reports demonstrating high efficiency of RDN in such patients propelled the development of the technology, yet a specific randomised controlled trial Symplicity HTN-3 did not show its benefits. Data from the subsequent RCTs SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED have shown that RDN reduces both office and daily blood pressure, does not depend on the patient adherence, and is efficient in patients with uncontrolled hypertension even in the absence of drug therapy. This review summarises the data on the efficacy and safety of the technology, its organoprotective effects, and also discusses the benefits of the RDN in different patient groups.
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Chichkova et al. (2020) conducted a review in resistant hypertension. Renal denervation (RDN) was evaluated. Renal denervation reduces both office and daily blood pressure, does not depend on patient adherence, and is efficient in patients with uncontrolled hypertension even without drug therapy.
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