Key result
Moderate intensity aerobic training altered type I collagen fiber volume and MMP-2, and reduced 8OHdG oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.
Why the study?
Coronary heart disease risk increases with menopause, physical inactivity, and dyslipidemia, leading researchers to investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice.
Does moderate intensity aerobic physical training improve myocardial collagen remodeling and oxidative stress in ovariectomized LDL knockout mice?
Does moderate intensity aerobic physical training improve myocardial collagen remodeling and oxidative stress in ovariectomized LDL knockout mice?
Moderate intensity aerobic training improves myocardial collagen remodeling and reduces oxidative stress in a mouse model of menopause and dyslipidemia.
Moderate aerobic training may mitigate cardiac remodeling and oxidative stress in menopausal dyslipidemia models; leaves open translation to human postmenopausal patients.
BACKGROUND: The emergence of coronary heart disease is increased with menopause, physical inactivity and with dyslipidemia. Physical training is known to promote the improvement of cardiovascular functions. OBJECTIVE: To investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice. METHODS: Thirty animals were divided into 6 groups (n = 5): Sedentary non-ovariectomized control; Sedentary ovariectomized control; Trained ovariectomized control; Sedentary non-ovariectomized LDL-knockout, sedentary ovariectomized LDL-knockout and trained ovariectomized LDL-knockout. We analyzed the average parameters of apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9, were considered significant p < 0.05. RESULTS: The results showed that the proposed exercise protocol altered the volume of type I collagen fibers, altered collagen remodeling parameters (MMP-2), and also reduced the 8-hydroxy-2'-deoxyguanosine (8OHdG) oxidative stress parameter. CONCLUSION: Moderate intensity aerobic training acts on collagen fiber volume, on collagen remodeling with the reduction of oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.
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Brianezi et al. (2019) studied Menopause and dyslipidemia model (n=30). Aerobic physical training vs. Sedentary control was evaluated on Apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9. Moderate intensity aerobic training altered type I collagen fiber volume and MMP-2, and reduced 8OHdG oxidative stress in the left ventricles of ovariectomized LDL-knockout mice.
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