Key result
Aerobic physical training did not generate significant structural alterations in the myocardium of hypercholesterolemic female LDL knockout ovariectomized mice.
Why the study?
Does aerobic physical training improve left ventricular morphological parameters in female LDL knockout ovariectomized mice?
Does aerobic physical training improve left ventricular morphological parameters in female LDL knockout ovariectomized mice?
Moderate aerobic physical training did not generate significant left ventricular morphological alterations in a mouse model of menopause and hypercholesterolemia.
Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.
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Brianezi et al. (2017) studied Hypercholesterolemia and menopause (LDL knockout ovariectomized mice) (n=30). Aerobic physical training vs. Sedentary control was evaluated on Myocardial structural parameters (nuclear volume, myocyte area, capillary density, collagen). Aerobic physical training did not generate significant structural alterations in the myocardium of hypercholesterolemic female LDL knockout ovariectomized mice.
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