Key result
An online-only pilot study of evening versus morning antihypertensive dosing successfully randomised 355 participants, establishing feasibility for a full trial.
Why the study?
Does evening dosing of antihypertensives improve cardiovascular outcomes compared to morning dosing in hypertensive adults?
Population
355 hypertensive adults prescribed at least one antihypertensive drug and having a valid email address, in…
Comparison
Evening dosing of antihypertensive therapy vs Morning dosing of antihypertensive therapy
Design
RCT, randomised, open-label, blinded end-point (PROBE)
Follow-up
≥ 12 months
Authors
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Supports large pragmatic trial of dosing timing; extends decentralized RCT methods to chronotherapy evaluation.
RCT (n=355)
Open-label, blinded end-point
randomised
Yes
Does evening dosing of antihypertensives improve cardiovascular outcomes compared to morning dosing in hypertensive adults?
An online-only, decentralized trial design is feasible for evaluating the timing of antihypertensive dosing, enabling a large-scale pragmatic trial.
Rorie et al. (2016) conducted an RCT in Hypertension (n=355). Evening dosing of antihypertensives vs. Morning dosing of antihypertensives was evaluated on Patient reported cardiovascular outcomes. An online-only pilot study of evening versus morning antihypertensive dosing successfully randomised 355 participants, establishing feasibility for a full trial.
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