Why the study?
Does evening dosing of antihypertensive medication reduce the composite of non-fatal MI, non-fatal stroke, or vascular death compared to morning dosing in hypertensive patients?
Population
Adults over 18 years of age prescribed at least one antihypertensive drug taken once a day, with a valid…
Comparison
Evening dosing of antihypertensive medication. vs Morning dosing of antihypertensive medication.
Design
RCT, Randomised, Open-label, blinded end-point (PROBE) design
Follow-up
Average 4 years
Authors
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Evening dosing hypothesis untested at scale; leaves open whether chronotherapy reduces CV events in hypertension.
Does evening dosing of antihypertensive medication reduce the composite of non-fatal MI, non-fatal stroke, or vascular death compared to morning dosing in hypertensive patients?
This paper describes the methodology for the TIME study, a large pragmatic trial evaluating whether evening dosing of antihypertensives improves cardiovascular outcomes compared to morning dosing.
Rorie et al. (2016) studied this question.
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