Polyketides from a marine medicinal brown alga-derived fungal strain Hypomontagnella monticulosa SC1047

This is the authors' abstract. We don't add key points for this paper.

In this study, a marine medicinal brown alga Sargassum cristaefolium -derived fungal strain Hypomontagnella monticulosa SC1047 was isolated and identified. The extracts from liquid-fermented products of the fungal strain were subjected to column chromatography , which yielded ten purified compounds. Their gross structures were characterized by spectroscopic analysis , and the absolute configurations were further established through modified Mosher's method and/or electronic circular dichroism spectroscopy. This analysis led to identification of six previously undescribed compounds, namely hypoketides A–F ( 1 – 6 ), along with four known compounds 7 – 10 . All the isolates were examined for anti-inflammatory and anti-angiogenic properties. Of the tested compounds, compounds 2 and 7 could moderately inhibit nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC 50 values of 4.9 ± 0.3 and 8.9 ± 0.1 μM compared to that of curcumin (IC 50 = 2.7 ± 0.3 μM). Compounds 1 , 2 , and 7 exhibited moderate to slight inhibitory effects on the growth of human endothelial progenitor cells with IC 50 values ranging from 21.6 ± 0.6 to 63.8 ± 1.8 μM compared to that of sorafenib (IC 50 = 4.8 ± 0.5 μM).