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January 1, 1970Japanese Circulation Journal-english EditionOpen Access

Experimental Studies of Coronary Insufficiency I. Changes in Myocardial Contractility in the Ischemic Area of the Ventricle Following Acute Coronary Occlusion

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Population

Anesthetized open-chest dogs

Design

Preclinical

Authors

SYShinji YoshidaPanasonic (Japan)

Discussion

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Implication

Highlights rapid contractile failure in ischemic canine myocardium; extends experimental models but leaves open human relevance.

Structured PICO

P
Population
Anesthetized open-chest dogs
I
Intervention
Acute and complete occlusion of the left anterior descending coronary artery
O
Outcome
Changes in myocardial contractility (developed tension)surrogate

Acute coronary occlusion in a canine model leads to rapid loss of developed tension within one minute, with a rightward shift in the resting length-developed tension curve during ischemia.

Cite This Study

Shinji Yoshida (1970) studied this question.

synapsesocial.com/papers/6a981609883af1d6c8a69307https://doi.org/10.1253/jcj.33.1253

Topics

Coronary CT angiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polarographic Oxygen, the Epicardial Electrocardiogram and Muscle Contraction in Experimental Acute Regional Ischemia of the Left Ventricle1958 · 157 citations
  2. 2Myocardial creatine phosphate and nucleotides in anoxic cardiac arrest and recovery1961 · 95 citations
  3. 3Biphasic Action of Acetylcholine on Ventricular Myocardium1965 · 99 citations
  4. 4The Mechanochemistry of Cardiac Muscle1967 · 72 citations
  5. 5Early Changes in Energy Metabolism in the Myocardium Following Acute Coronary Artery Occlusion in Anesthetized Dogs1968 · 240 citations