Key result
Neither serum nor urine Angptl4 are specific biomarkers for minimal change disease, as elevated urinary Angptl4 reflects the degree of proteinuria across various glomerular diseases.
Observational (n=182)
Yes
Neither serum nor urine Angptl4 appear to be specific biomarkers for minimal change disease; rather, elevated urinary Angptl4 reflects the degree of proteinuria across various glomerular diseases.
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Angptl4 should not guide minimal change disease diagnosis; leaves open its role as a general proteinuria marker pending prospective studies.
BACKGROUND: Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker in MCD. METHODS: Patients with biopsy-proven primary MCD, focal segmental glomerulosclerosis, membranous nephropathy (60, 52 and 52 respectively) and 18 control subjects had urinary and serum Angptl4 measured by Elisa. Frozen kidney tissue sections were stained for Angptl4. RESULTS: Angptl4 was not identified in glomeruli of MCD patients in relapse. Urinary Angptl4 levels were elevated in MCD in relapse as well as in patients with massive proteinuria due to other glomerular diseases. CONCLUSION: Neither serum nor urine Angptl4 appear to be good biomarkers in MCD. Elevated urinary Angptl4 n glomerular disease appears to reflect the degree of proteinuria rather than any specific disease.
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Cara‐Fuentes et al. (2017) conducted an observational in Minimal Change Disease (n=182). Angiopoietin-like-4 (Angptl4) vs. Control subjects and patients in remission was evaluated on Urinary and serum Angptl4 levels (p=<0.0001). Neither serum nor urine Angptl4 are specific biomarkers for minimal change disease, as elevated urinary Angptl4 reflects the degree of proteinuria across various glomerular diseases.
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